Extend Your Life...Soon

So here's the news...
New study explains duality of longevity drug rapamycin 
A Penn- and MIT-led team explained how rapamycin, a drug that extends mouse lifespan, also causes insulin resistance. The researchers showed in an animal model that they could, in principle, separate the effects, which depend on inhibiting two protein complexes, mTORC1 and mTORC2, respectively.
Getting mice to live longer is a feat that's been pulled off in the past by various methods. The trick is to get one of these techniques to work for people. Rapamycin looked like a promising approach -- its benefits might well map to human subjects and you don't have to restrict calories or any of that kind of stuff. But that business about causing insulin resistance is no small thing. The problem was typically shorthanded to "you live longer, but you get diabetes."

Probably not. Insulin resistance is associated with more than diabetes. There's obesity, hypertension, high cholesterol -- actually you can package it all up into what they're now calling metabolic syndrome. And metabolic syndrome is about as un-life-extension-favoring a condition as you would want to have, short of terminal cancer or stepping in front of a speeding truck.

Basically you live longer, but you die sooner. Not much of a deal.  So there was a two-item checklist for rapamycin:

  1. Find a way to have it not cause insulin resistance.
  2. Find out if it works with people

It doesn't appear that the researchers above have quite ticked off item one yet, but they're getting there. Let's make that happen and then move on to item 2.

As far as I know -- and I'm sure someone will correct me if I'm wrong -- if this were to work it would be the first medication ever developed that directly increases lifespan...as opposed to making you live longer by helping you not die from one thing or another. That would be a huge step forward.

Once we have one such treatment, we'll be looking for others.

If you're serious about getting started with life extension, there's still time to sign up for Christine Peterson's Personalized Life Extension Conference, the actual event or the live webcast. Here's our recent interview with Christine for those who missed it.


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